Neuropathic Pain

Neuropathic Pain

What is Neuropathic Pain?

Neuropathic pain, also known as peripheral neuropathy, neuralgia or nerve pain, is a condition that involves damage or dysfunction of the peripheral nerves. These nerves are responsible for transmitting signals between the central nervous system (the brain and spinal cord) and the rest of the body, including the limbs, organs, and skin. Neuropathy can manifest in various ways. And, it can affect different types of nerves, leading to a wide range of symptoms. Common symptoms of neuropathy include:

  • Tingling and numbness: Individuals with neuropathy often experience a sensation of pins and needles. It can also cause numbness in the affected areas.
  • Burning or shooting pain: Many people with neuropathy describe feeling a burning pain, electric shock-like sensations, or shooting pains. These pains can be intermittent or constant.
  • Muscle weakness: Neuropathy can lead to muscle weakness, making it difficult to perform everyday tasks or maintain balance.
  • Sensitivity to touch: Some individuals may become hypersensitive to touch or experience pain when even a light touch is applied to the affected areas.
  • Loss of coordination: Neuropathy can affect motor skills and coordination. Hence, it can lead to difficulties in walking and performing fine movements.
  • Autonomic dysfunction: In certain cases, neuropathy can also affect the autonomic nervous system. This can lead to problems with blood pressure regulation, heart rate, digestion, and other involuntary bodily functions.

Underlying Causes of Neuropathic Pain

  • Diabetes: Diabetic neuropathy is a common form of neuropathy. It is caused by long-term high blood sugar levels damaging the nerves.
  • Cancer Related Pain: Pain is one of the most common symptoms of cancer. And, it can also be caused by cancer treatments.
  • Phantom Limb Pain: The perception of pain in a limb that is no longer there.
  • Trauma or injury: Physical injuries, such as car accidents or falls, can damage nerves and lead to neuropathy.
  • Vitamin deficiencies: Lack of certain vitamins, particularly B vitamins like B12, can lead to nerve damage.
  • Infections: Some infections, like shingles, Lyme disease, and HIV, can cause neuropathy.
  • Autoimmune disorders: Conditions like rheumatoid arthritis, lupus, and Guillain-Barré syndrome can lead to nerve damage.
  • Toxic exposure: Exposure to certain toxins, such as heavy metals, certain medications, and chemotherapy drugs, can cause neuropathy.
  • Heredity: Some forms of neuropathy are inherited and run in families.
  • Idiopathic: In some cases, the cause of neuropathy is unknown, and it's referred to as idiopathic neuropathy.

Treatment for Neuropathic Pain

Treatment for neuropathy depends on the underlying cause and the specific symptoms. Managing the underlying condition, if possible, can help alleviate neuropathic symptoms. Medications, pain management strategies, physical therapy, and lifestyle changes may also be recommended to manage the pain. And, improve quality of life for individuals with neuropathy. It's important to work closely with a healthcare provider to determine the most appropriate treatment approach.

How Does Ketamine Work to Treat Neuropathy?

Neuropathic pain, often described as shooting, burning, or tingling sensations, can be a debilitating condition resulting from damage or dysfunction of the nervous system. Neuropathic pain arises from the miscommunication between the nerves, spinal cord, and brain. It can be caused by various factors. These include nerve injuries, diabetes, viral infections, or chronic diseases like multiple sclerosis. Unlike nociceptive pain, which is the body's normal response to injury, neuropathic pain persists even after the initial cause has healed.

Managing neuropathic pain has proven challenging. Traditional treatments, such as opioids, non-steroidal anti-inflammatory drugs (NSAIDs), and anticonvulsants, often provide limited relief and come with undesirable side effects. Moreover, these treatments do not address the root cause of the pain. Hence, this leads to long-term reliance on medications. This condition poses a significant challenge to both patients and medical professionals due to its complex and difficult-to-treat nature. However, ketamine has emerged as an outstanding treatment option.

Originally developed as a general anesthetic in the 1960s, ketamine quickly gained popularity due to its unique characteristics. During its early use, doctors noticed that patients who received ketamine as an anesthetic experienced unexpected relief from chronic pain conditions, including neuropathic pain.

To understand how ketamine works to treat neuropathic pain, we must explore its mechanism of action within the brain. Ketamine acts on a particular receptor known as the N-methyl-D-aspartate (NMDA) receptor. The NMDA receptor plays a crucial role in modulating the transmission of pain signals in the central nervous system.

In the context of neuropathic pain, an excessive release of the neurotransmitter glutamate leads to the overactivation of NMDA receptors. This hyperactivity results in increased pain sensitivity and the amplification of pain signals. Ketamine's main role is to block these NMDA receptors, reducing their overstimulation and subsequently dampening pain signals.

Neuroplasticity and Ketamine

Another crucial aspect of ketamine's pain-relieving properties lies in its ability to enhance neuroplasticity. This is the brain's capacity to reorganize and form new neural connections. Chronic pain conditions can cause maladaptive changes in the brain. This makes the pain experience more intense and persistent. Ketamine's impact on neuroplasticity helps to reverse some of these maladaptive changes and promote healthier neuronal connections.

Rapid Onset and Short Duration of Action

One of the remarkable features of ketamine as a neuropathic pain treatment is its rapid onset of action. Traditional analgesics that may take days or weeks to take effect. Whereas, ketamine often provides relief within minutes to hours after administration. However, its pain-relieving effects are relatively short-lived, lasting for several days to a week. This necessitates carefully timed and monitored dosing schedules.


Ketamine Treatment Plan for Neuropathy

Ketamine treatment for neuropathy generally requires the administration of multiple IV infusions. This is a case where more ketamine can yield better pain relief and the safest way to infuse more ketamine is by using longer infusion times. Options range from high-dose, 1-hour infusions to 4-hour infusions based on individual response. There can be a tradeoff between having a longer, more intense infusion that provides longer lasting benefit versus coming in more frequently for shorter infusions. This can be an intense process for some. But, we always proceed one step at a time with safety being the primary concern. The treatment should only be performed by qualified healthcare professionals. And, the treatment should be administered in a controlled environment due to the risks associated with ketamine use.

Caution and Considerations

While ketamine shows significant promise in treating nerve-related chronic pain conditions, it is essential to undergo a thorough screening prior to initiating treatment. Most patients can safely receive ketamine therapy. There are a few medical conditions that might require treatment prior to beginning therapy or stop you from receiving this treatment. A few examples are uncontrolled hypertension, active substance abuse, pregnancy or unstable cardiac disease. Ketamine is not a first-line or stand-alone treatment for chronic pain and is intended to be one component of a multimodal treatment regimen.

Although the potential for addiction is extremely low, ketamine can be abused or misused. Close monitoring by qualified medical professionals is crucial during ketamine administration to ensure safety and appropriate dosing.


Ketamine's role in treating neuropathic pain presents a beacon of hope for those who suffer from this debilitating condition. Its unique mechanism of action, particularly on the NMDA receptor and neuroplasticity, sets it apart from traditional analgesics. However, it is essential to acknowledge that ketamine therapy requires close medical supervision and is not suitable for everyone. As research in this field continues to advance, we can hope for more effective and targeted treatments for neuropathic pain, improving the quality of life for countless individuals worldwide.

If you have not found sufficient relief using other treatments, please contact us to schedule a free consultation to discuss ketamine infusion therapy.